A Phase 1/2 trial included 15 individuals in total, among them three pediatric patients. The patients all suffered from the disease Leber congenital amaurosis caused by a gene that is essential in making proteins crucial to vision.
The rates of heart failure events and cardiovascular death were lower in the finerenone group compared with the placebo group.
This new research, published in Alzheimer’s & Dementia, suggested that the cognitive impairments of COVID-19 presented similar fundamental changes within the brain to those showing evidence of dementia.
A landmark 2018 study, Garvan scientists were the first in the world to directly observe i-motifs inside living human cells using a new antibody tool they had developed, that was able specifically to bind to them.
It is like the communication network that genes have among them to affect one another.
The researchers collected several thousand cells in each brain from a region of the brain that is affected by Alzheimer’s and ageing.
Here the investigators infected mice with SARS-CoV-2 and sequenced the genomes of viruses replicating in the brain versus the lung. In the lung, spike protein had a very close structure to the infecting virus.
Mitochondria live in all our cells, but unlike other organelles, mitochondria sport their own DNA—a small, circular strand with about three dozen genes.
Naturally, the code depends upon the assistance of massive proteins called transcription factors, which determine which genes in one’s genome are turned on or off.
The researchers focused on mouse retinal ganglion cells in the study, which project from the retina to the superior colliculus a part of the brain where they synapse onto downstream target neurons.
