One of the novel synthesis’s key features is a bioinspired photooxygenation-allylic hydroperoxide rearrangement sequence that makes it easier to add functional groups in the synthesis’s final stages.
Disease Biology
A diagnosis of the underlying pathology is required for the development of therapies and for stratifying patients according to their disease.
The researchers discovered that a statin called pitavastatin efficiently decreases IL-33 expression by preventing the activation of the TBK1-IRF3 signalling pathway.
When the medication was given to mice whose tumors had been surgically removed, similar results were also shown.
The drug is special, say the researchers, since it specifically targets the beta cells in the pancreas that produce insulin and is made to protect those cells against the immune system attacks.
Methylation of mRNA impairs the brain’s energy supply by interfering with the synthesis of ND5, a subunit of complex I of the respiratory chain.
Researchers at Umeå University demonstrate that a novel gene treatment has significantly slowed down the disease development in a patient with an extremely severe type of ALS illness.
To increase the efficacy of treatment, scientists from Virginia Tech’s College of Engineering have created a novel cancer immunotherapy that targets cancer-killing cytokines where they are found in tumours.
On World Parkinson’s Day, a new hypothesis study combines the body-first and brain-first theories with environmental toxicants that may be consumed or breathed as potential origins of the condition.
Novel immunotherapies like CAR T-cell therapies may not be effective in treating aggressive types of blood cancer due to a unique mutation in the cancer cells.
